Tuesday, April 23, 2013

CA Acquires Layer 7 Technologies To Connect Cloud, Mobile And Internet Of Things As API Market Starts To Consolidate

ca_logo_rCA Technologies announced this morning that it has acquired API management company Layer 7. It is the second major acquisition of an API management company in the past week, signaling a consolidation of a market that larger companies see as?vital?for closing the gap between on-premise and online infrastructure and apps. Last week, Intel acquired Mashery for $180 million. The?acquisition?price for Layer 7 was not?disclosed?but the Mashery price serves as ?a good guide for what CA was ready to pay. CA also?announced?it is buying?Nolio, a company that provides ?continuous application delivery. In a press release, ?CA said its solution combined with Layer 7 will help organizations to better manage and secure APIs and better deliver applications in the?cloud across mobile and web environments. CA said the?acquisition?will help: Securely enable strategic?cloud, mobile and ?Internet of Things? initiatives through API security and management Accelerate service delivery and increase profitability by externalizing and monetizing existing application assets that are securely offered via APIs Expand the network of API developers by offering a convenient API development platform that provides all the tools necessary to discover, publish and test APIs Govern API activity in order to enforce SLAs, improve operational performance and monetize big data transactions Secure the externalized API business through authentication, authorization, auditing and threat protection. Layer 7 is considered one of the leaders in the API management space. It competes with Mashery and providers such as Apigee, which remains an?independent?company. The space also encompasses back-end-as-a-service (BaaS) providers such as Kinvey, Parse and Stackmob. APIs have long been a staple for app developers. With the advent of REST-based APIs, the web and mobile app space boomed, providing the means to ?integrate multiple services in one application. With today’s enterprise, the need is to integrate online and on-premise architectures. It becomes important to build a layer around applications that can be connected with APIs ?to pull out relevant information that feeds into other systems. That strategy seems to be a part of what makes Layer 7 appealing to CA. The acquisition appears complenentary to the Nolio purchase, which “reinforces the enterprise evolution of DevOps ? the confluence of application development and deployment via IT operations?, said 451 Research Senior Analyst Jay Lyman. He goes on to explain ?how more enterprise and service-provider customers are implementing automation, continuous deployment and DevOps more broadly.” That puts CA in a spot to provide a next generation of IT

Source: http://feedproxy.google.com/~r/Techcrunch/~3/rL3QZ9Xxirg/

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Monday, April 22, 2013

Thursday, April 18, 2013

10 Things to Know for Thursday

Your daily look at late-breaking news, upcoming events and the stories that will be talked about Thursday:

1. INVESTIGATORS SEEK A SUSPECT

Department-store surveillance video captured a man dropping off a bag at the site of the Boston Marathon bombings.

2. HOW THE BATTLEFIELD IS HELPING BOMB VICTIMS

The wars in Iraq and Afghanistan have led to medical advances that are now being used to treat amputees in Boston.

3. MAN IN MISSISSIPPI ARRESTED IN RICIN CASE

He's accused of mailing letters with suspected poison to Obama and other leaders.

4. GUN CONTROL DIES IN THE SENATE

The Republican-led body rejects tighter background checks and other measures despite pleas from families of Newtown victims.

5. WOMAN IMPLICATES HUSBAND IN TEXAS SLAYINGS

She alleges that the ex-judge fatally shot the local DA and two others he apparently blamed for the loss of his job.

6. WHAT PEOPLE AREN'T BUYING IN EUROPE

Car sales have declined for 18 months in a row amid worries about the economy and soaring unemployment.

7. DEMOCRAT VOICES WARNING ON HEALTH CARE

The head of the Senate Finance Committee says he fears the rollout of Obama's overhaul will be a "train wreck."

8. ASSAD GIVES RARE TV INTERVIEW

He accuses the West of backing al-Qaida in Syria's civil war ? but offers no evidence.

9. WHO'S FLEEING PUERTO RICO

Many doctors and nurses in search of better pay are moving to the U.S. mainland.

10. FROM A GALAXY FAR, FAR AWAY TO A THEATER NEAR YOU

Disney says it plans to release a "Star Wars" film each summer starting in 2015.

Source: http://news.yahoo.com/10-things-know-thursday-104756375.html

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Wednesday, April 17, 2013

LG to 'Share the Genius' May 1 in NYC

LG Share the Genius

A mic on a stage, eh? Not sure what LG's got up its sleeves for May 1 in New York City, but it wouldn't surprise us in the least to see the excellent LG Optimus G Pro make an appearance in its U.S. form, especially with recent rumblings of it hitting AT&T shortly thereafter. (Check out our mini review of the Korean version if you've yet to do so.) "Share the Genius" likely is a nod to the software features on the phone, which LG is more than happy to tell you it had before its Korean neighbor. And "Capture the Spotlight in True Brilliance" fits perfectly with the Optimus G Pro's excellent 5.5-inch 1080p IPS display.

So, yeah. Set your calendars, folks.

    


Source: http://feedproxy.google.com/~r/androidcentral/~3/oYvAwpGVvh8/story01.htm

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Tuesday, April 16, 2013

Shady Oak Stable

I'm glad that you approve of it all. :D I understand completely about the whole age thing, she will most likely be eighteen.. newly legal, hehe.
Thanks, I will have you a sample by tomorrow evening, if that's alright. I definitely like your style on how you go about things! :T Is there a certain situation or anything you'd like my writing sample to be about? Or just whatever, as long as it involves the character I'll be portraying in this role-play? I don't mind if you have a certain scenario in mind for me. I'm flexible.

(And I'll keep that in mind (question asking, that is). I'll probably have a couple for you eventually. I like making sure I have everything down so I can portray the role of my character correctly. ^-^)

Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/ngzGhUlIox0/viewtopic.php

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91% Jurassic Park: An IMAX 3D Experience

All Critics (94) | Top Critics (24) | Fresh (93) | Rotten (8) | DVD (38)

The enthralling man-vs.-nature parable based on the late Michael Crichton's best-selling novel hasn't aged one bit.

The 3-D process adds not just dimension but depth - a technological extension of cinematographer Gregg Toland's deep-focus innovations in The Grapes of Wrath and Citizen Kane. The change in perspective creates greater intensity.

I'm a fan of this movie. It is thrilling, and the 3-D treatment is a nice enhancement.

This movie doesn't just stand the test of time, it transcends it.

"Jurassic Park" remains an absolute thrill from a Spielberg in top form: Funny, scary, fast-moving and full of just-right details.

"Jurassic Park" was impressive in 1993. Twenty years later, it's flawless.

[Looks] better not only than effects-driven movies of the same period, but better, frankly, than half of what gets released nowadays.

Kids who love dinosaurs will love it. And who doesn't?

confirms both Spielberg's mastery of cinematic thrills and the comparatively empty bombast of today's summer tentpole movies, even the better ones.

Jurassic Park shows us a director in transition, and the film captures his transformation in its own kind of cinematic amber.

[The] 3D [conversion] provides the definitive version of this classic film. Jurassic Park has been transformed with with artistry, nuance and sophistication, and it's an absolute must-see during this brief run.

The 3D effects had me nearly jumping out of my seat. Some say Hollywood is converting too many old films to 3D. But, "Jurassic Park" was the perfect choice. There's nothing more fun than sharing a seat with a snapping dinosaur.

Spielberg treats us as he does his characters, leading us into a strange land and expecting us to make it out with all our faculties intact; it's a tall order, given the heart-stopping, bloodcurdling, limbs-numbing excitement packed into the second hour.

It is as if time has passed the movie by. "Jurassic Park" remains solid entertainment, but the awe and wonder have faded.

The thrill of seeing live dinosaurs on screen is not as acute today as it was 20 years ago admittedly, but there is still some 3D awe left in the creations that roared 65 billion years ago...

The 3D isn't pushed on the audience, but it does reveal the amount of depth that Spielberg actually put into the film 20 years ago.

While it's not the most profound of Spielberg's works or the most entertaining from a popcorn perspective, it's one of the most technically flawless movies he's ever produced.

Jurassic Park 3D is like being reunited with an old friend; an old friend that wants to eat you and maul you to death, but still. A classic is reborn in glorious IMAX with a vibrantly stunning use of 3D.

If releasing the film in 3-D is the only way to get it back in theaters, then the gimmick is an acceptable addition. The 3-D is good. But when a movie is this near flawless, nothing is needed to make it better.

The 3D conversion ruins everything, like the comet that killed the dinosaurs, making Jurassic Park the rare amusement I'd prefer to revisit at home.

A beast of a movie is gifted a superfluous-but-superb rouging of the cheeks, offering fanatics something new to study while newcomers will be ruined for any future television airings.

The tasteful Jurassic Park 3D conversion injects new wonder and excitement into one of the most captivating adventure movies ever made.

There is nothing like experiencing this fabulous, larger-than-life, groundbreaking movie where it was meant to be experienced. And in 3D!

This is an immensely entertaining film, as long as you can overlook the many minor flaws that permeate its structure. (Complete Content Details for Parents also available)

But really, what makes "Jurassic Park" great is that it is a Steven-Spielberg-master-class in constructing action set-pieces.

Source: http://www.rottentomatoes.com/m/jurassic_park_an_imax_3d_experience_1993/

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Asia-Pacific Countries Conduct Maritime Disaster Response Exercise (Voice Of America)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS Feeds and Widgets via Feedzilla.

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Monday, April 15, 2013

93% Room 237

All Critics (98) | Top Critics (25) | Fresh (92) | Rotten (7) | DVD (1)

The results can range from enlightening - Kubrick did like to mess with things - to embarrassing. But it's never dull. "Room 237" shines.

You don't have to buy any of the nutty theories in Room 237 to appreciate what director Rodney Ascher has accomplished.

It's nuts, in the best possible way.

Their imaginings are not far removed from the deconstuctionist gobbledygook that has hammerlocked academic film and literary scholarship. But here at least the gobbledygook is entertaining.

[It] may be the surpassingly eccentric-and enormously entertaining-film that Kubrick deserves.

"Room 237" is an act of uncommon devotion to cinema, embracing the notion that movies are best defined by what happens to us as we watch them - how our own beliefs and experiences dictate our interpretation of what we've seen and heard.

Powered by a deep and abiding affection for both The Shining and Kubrick in general, Room 237 is an amuse-bouche of remix culture.

Room 237 is an extended riff of the "Paul is dead" variety. But, you know what? Sometimes a guy moving a table in the background is just a guy moving a table in the background.

A diverting excursion for lovers of Kubrick's films...even if, at over a hundred minutes, it does go on a bit long.

A fascinating doc that will get both film geeks and conspiracy theorists alike drooling, it all but guarantees you'll never watch The Shining quite the same way again.

Confounding, eye-opening, and often hilarious.

I suspect that Ascher's intention was to dynamize an academic exercise, but these constant, sundry inserts render the tone as corny and glib as a VH1 special.

The thrill's in the thinking about little pieces of cinematic language as words contributing to a two-hour essay.

Would it be hypocritical to say that I loved "Room 237," even thought I felt like 75 percent of what was said in it was completely hooey?

a journey down a rabbit hole worth taking, as the film immerses us in alternately fascinating, compelling, absurd, and frightening theories about what, exactly, The Shining is (or might be) about

Room 237 is both an ode to the subversive nature of the movies and a fascinating insight into clashing obsessions in its most lurid form, even when its stylistic choices seek to destroy the experience.

I can't buy into the notion of Stanley Kubrick faking Apollo 11's moon landing but he definitely helped Shelley Duvall fake a movie career.

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Source: http://www.rottentomatoes.com/m/room_237_2012/

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Sunday, April 14, 2013

Steve Sailer: iSteve: L.A. Times: "Immigration bill would spark surge ...

From the L.A. Times:

Immigration bill would spark surge of legal arrivals?
The immigration debate often focuses on people in the U.S. illegally, but a reform bill's biggest initial effect could be a sharp rise in legal immigration.

By Brian Bennett and Lisa Mascaro, Washington Bureau ?

April 13, 2013, 8:13 p.m.?
WASHINGTON ? While much of the debate over immigration has focused on the fate of the estimated 11 million people in the U.S. without legal authorization, one of the biggest immediate impacts of the reform bill being prepared in the Senate would be a sudden, large surge in legal migration.?
The U.S. admits about 1 million legal immigrants per year, more than any other country. That number could jump by more than 50% over the next decade under the terms of the immigration reform bill that a bipartisan group of senators expects to unveil as early as Tuesday. The impact would be felt nationwide, but areas that already have large immigrant communities would probably see much of the increase.?
The immigration package includes at least four major provisions that would increase the number of legal immigrants, according to people familiar with it. Some of the parts could generate as much controversy as the provisions dealing with those who enter the country illegally or overstay their visas, according to those with long experience of the politics of immigration.?
Supporters say that higher levels of legal immigration would meet the U.S. need for certain kinds of workers. Increased legal migration also would reduce most of the incentive for illegal border crossings, backers of the plan say, and would allow border agents to focus on smugglers and people with violent criminal records.?
Opponents such as Sen. Jeff Sessions (R-Ala.), who has long opposed measures to increase immigration levels, say new workers would depress wages and crowd out Americans looking for work during a time of persistently high unemployment.?
"The masters of the universe in glass towers and suites, they may not be impacted by this, but millions of struggling American families will," Sessions said in an interview Friday. "We do need to be sure we aren't exacerbating unemployment and wage erosion in America."

Good first sentence, Jeff. Work on the second one.
The surge would come in several ways: The bill aims to eliminate the current backlog of roughly 4 million people waiting to be reunited with family members in the U.S. The 11 million now in the country without legal authorization would be eligible for citizenship only after that backlog was resolved. Reunification efforts would require boosting the number of visas issued each year.

You know, if they really want to reunite, they can always go home.
To keep the additional inflow under control, the bill would stop allowing adult siblings of immigrants to qualify, but children and parents would continue to be eligible.?
In addition to family unification, which allows people into the country permanently, the bill also aims to increase temporary visas for both high-wage and low-wage workers. The number of visas for high-tech workers could nearly double to more than 120,000 per year.

Because Mark Zuckerberg isn't rich enough.
At the other end of the wage scale, a new visa system would allow businesses to bring in workers for jobs including janitors, housekeepers and meatpackers.

Because nothing says well-paid like janitor, housekeeper, or meatpacker. Because nothing says high test scores like the children of janitors, housekeepers, and meatpackers.
The numbers would start small, but as the unemployment rate declined, it could reach 200,000 a year by the end of the decade. And growers could bring a total of about 330,000 new farmworkers into the country during the decade. At least some of those low-wage temporary workers eventually would be allowed to seek permanent residency.
The bill's authors expect that legal immigration eventually would decline again, but only 10 years after the bill passed, once the backlog of residency applications shrank.


Just keep repeating to yourself: "But it's good for The Economy. Who am I to stand in the way of The Economy? The Economy doesn't exist for me, I exist for The Economy."


Source: http://isteve.blogspot.com/2013/04/la-times-immigration-bill-would-spark.html

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Saturday, April 13, 2013

Make a Surprisingly Stylish Lamp Out of Three Sticks and a Lightbulb

Make a Surprisingly Stylish Lamp Out of Three Sticks and a LightbulbThe best DIY projects are useful, simple, and inexpensive. On rare occasions they're also beautiful. Such is the case with the Tres Lamp, a small source of lighting created out of three sticks and a lightbulb by Instructables user Tim Wikander.

The project couldn't be more simple. All you need is natural fiber cording, a plug, a lightbulb, a socket to match that bulb, three dowel rods, and some simple tools like a handsaw and wire cutters. With that, you can make the beautiful lamp pictured above. For the entire how-to, hit up the full post over at Instructables.

Tres Lamp | Instructables

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/NH64d-KukfM/make-a-surprisingly-stylish-lamp-out-of-three-sticks-and-a-lightbulb

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Friday, April 12, 2013

Toyota, Honda, Nissan to recall 3.4 million cars worldwide

By Yoko Kubota

TOKYO (Reuters) - Four Japanese automakers including Toyota Motor Corp, and Nissan Motor Co are recalling 3.4 million vehicles sold around the world because airbags supplied by Takata Corp are at risk of catching fire or injuring passengers.

The move announced on Thursday is the largest recall ever for airbags made by Takata, the world's second largest supplier of airbags and seatbelts. Shares of Takata tumbled almost 10 percent in Tokyo trading.

The recall is the largest since Toyota pulled back more than 7 million vehicles in October. The scale of the recent safety actions underscore the risk of huge global supply chain problems as automakers increasingly rely on a handful of suppliers for common or similar parts to cut costs, analysts have said.

The recall covers some of the top-selling Japanese cars, including Toyota's Camry and Corolla, and rivals like the Nissan Maxima and Honda Civic. All of the vehicles in question were manufactured in or after 2000.

In an accident, the airbag for the front passenger seat may not inflate correctly because of a manufacturing defect in the propellant used in the airbag inflator, the companies said. As a result, there is a risk of fires starting or of passengers being injured.

Toyota, Honda and Nissan said there were no reports of injuries or deaths because of the defective airbags.

The recall is the largest for Takata since 1995 when the Tokyo-based company was involved in a recall of over 8 million vehicles because of defective seatbelts.

Tokyo-based Takata said it supplies airbags and seatbelts to major automakers including Daimler AG and Ford Motor Co as well as the Japanese brands.

Some non-Japanese automakers were also supplied with the faulty airbags, Takata spokesman Toyohiro Hishikawa said. He declined to name those automakers.

DEFECT FOUND

Between 2008 and 2011, Honda Motor Co was forced to recall about 2.8 million vehicles after finding a defect with driver-side airbags supplied by Takata.

"When the last recall took place, we inspected everything such as the site of manufacturing, but we were not able to identify this problem," said Hideyuki Matsumoto, another spokesman for Takata.

Toyota said it would recall about 1.73 million vehicles produced between November 2000 and March 2004, including 580,000 vehicles sold in North America and 490,000 vehicles sold in Europe.

Honda said it was recalling around 1.14 million vehicles worldwide. Nissan Motor Co said it was recalling about 480,000 vehicles globally. It said the number of vehicles under recall could increase. Mazda Motor Co said it was recalling 45,500 vehicles worldwide.

The faulty airbags were manufactured between 2000 and 2002 in a Takata factory in Mexico.

The Toyota models covered by the recall include the Corolla, Tundra, Yaris and Camry. Nissan models include the Maxima and the Cube.

Toyota will exchange the faulty airbag inflators for new ones, a fix that is expected to take about an hour to two-and-a-half hours for most models, Toyota's Sakai said. He declined to give the costs related to the recall.

"The inflators themselves are not so expensive, but there is the cost to cover for the hours spent to fix the problem," said Kohei Takahashi, an auto industry analyst at J.P. Morgan in Japan.

The recall, announced during Japanese trading hours, hit Takata's shares harder than it did shares in the automakers, which typically carry reserves for recalls and warranty costs.

Shares in Toyota, Honda, Nissan and Mazda, which continue to be supported by a weakening yen, were up between 3.1 and 5.8 percent, outpacing a 2 percent rise in the benchmark Nikkei. ($1 = 99.5050 Japanese yen)

(This story adds the dropped word "million" in the first paragraph)

(Reporting by Yoko Kubota and Mari Saito; Editing by Daniel Magnowski)

Source: http://news.yahoo.com/toyota-recall-1-73-million-vehicles-worldwide-due-052253598--sector.html

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Stolen Laptop Is Sending Its Owner Secret Photos From Its New Home in Iran

Dom Del Torto is an animator currently living in the UK. Dom Del Torto's laptop is a MacBook Pro currently living 3,000 miles away in Iran. This was not a planned separation. More »
    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/4VLoHhZfGEM/stolen-laptop-is-sending-the-owner-secret-photos-from-its-new-home-in-iran

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Sinkhole swallows homes in Russia

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Source: http://feeds.nbcnews.com/c/35002/f/653387/s/2a9587f0/l/0Lvideo0Bmsnbc0Bmsn0N0Cid0C51494393/story01.htm

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Wednesday, April 10, 2013

CA-BUSINESS Summary

TSX posts year's biggest jump on upbeat China data

TORONTO (Reuters) - Canada's main stock index recorded its biggest one-day percentage jump in more than four months on Tuesday as positive economic data from China fueled hopes for a global economic recovery and drove gains in the material and energy sectors. The sharpest reaction came from gold producers, which were buoyed by a rise in the price of bullion and jumped 3.4 percent.

Agrium sweeps proxy vote, Jana cries foul

CALGARY, Alberta (Reuters) - Canadian fertilizer company Agrium Inc said on Tuesday its entire slate of directors had been elected to its board, defeating a rival slate nominated by dissident U.S. shareholder Jana Partners. Jana, the hedge fund that is Agrium's biggest single shareholder, said the vote was tainted and should be investigated. Agrium said the result was "fair and square".

Penney, Macy's court fight comes down to plastic pitchers

NEW YORK (Reuters) - The legal battle between Macy's and J.C. Penney over who gets to sell what Martha Stewart products took a comedic turn on Tuesday when lawyers asked a judge to weigh two pitchers in his hands, one from each of the rival retailers. At stake is the question of whether Penney violated the judge's order not to sell certain Stewart products.

Exclusive: Thermo bids for Life Technologies as buyout firms circle - source

NEW YORK (Reuters) - Thermo Fisher Scientific Inc made a binding offer for Life Technologies Corp on Tuesday as private equity firms raced to finalize a consortium to take the genetic testing equipment maker private, several people familiar with the matter said. Thermo Fisher met a bid deadline on Tuesday but private equity firms working on a joint bid missed it and were working late into the evening to secure the equity required to support an offer, the people said.

Porter Airlines expansion plan could hit hurdles

TORONTO (Reuters) - Canadian regional carrier Porter Airlines is expected to announce an order for 12 of Bombardier Inc's new CSeries jets on Wednesday, a likely challenge to flight restrictions at its Toronto Island airport base. The privately held airline, which says it will announce "expansion plans" at a morning press conference, could create a third cross-country carrier with the deal, ratcheting up competition for Canada's No. 1 and No. 2 airlines, Air Canada and WestJet Airlines Ltd .

Capmark's $147 million lawsuit against Goldman thrown out

NEW YORK (Reuters) - A federal judge halted a bid by real estate lender Capmark Financial Group to recover $147 million from Goldman Sachs in connection with alleged conflicts of interest stemming from Capmark's debt restructuring. In a written ruling on Tuesday, U.S. District Judge Robert Sweet in Manhattan said Capmark's arguments were barred because they contradicted statements it made in 2010, while bankrupt.

Canada ready for Canadian $1 billion sanctions against U.S. over labels

OTTAWA (Reuters) - Canada is prepared to impose sanctions of up to C$1 billion ($980 million) a year against the United States unless it complies with a WTO order to redesign its meat labels, Agriculture Minister Gerry Ritz said on Tuesday. The United States introduced country of origin labels for meat in 2009. Mexico and Canada successfully argued before the World Trade Organization that the labels were discriminatory and Washington has until May 23 this year to change them.

FBI probes trading as KPMG quits Herbalife, Skechers audits

(Reuters) - In a blow to one of the world's largest accounting firms, KPMG said it resigned as auditor of two U.S. corporations amid an FBI investigation into insider trading allegations involving leaked information and a former senior partner. The two California-based companies - nutritional products group Herbalife Ltd and footwear maker Skechers USA Inc - said separately on Tuesday that KPMG had quit as their auditor in connection with the leaks.

Scotiabank CEO sees Canadian housing slowdown, not crash

TORONTO (Reuters) - Bank of Nova Scotia Chief Executive Rick Waugh said on Tuesday that mortgage delinquencies have risen at Canada's third-biggest bank, but that he does not foresee a U.S.-style housing crash. "We still anticipate what I would call in terms of housing, a soft landing, and all the metrics which we watch daily confirm that," Waugh told the bank's annual general meeting in Halifax, Nova Scotia.

United Airlines plans earlier flights with Boeing 787

(Reuters) - United Airlines said on Tuesday that it planned to begin flying Boeing's 787 Dreamliner five days sooner than previously expected, a sign of confidence in the jet's return to service after regulators grounded it in January over safety concerns. United, a unit of United Continental Holdings Inc , said it planned to use Boeing's newest jet on its Denver-Houston route starting May 31 and on the Denver-Tokyo's Narita route beginning on June 10.

Source: http://news.yahoo.com/ca-business-summary-001749505--finance.html

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Can Student Finance change the amount of my loan/grant? Half way ...

Can Student Finance change the amount of my loan/grant? Half way through the year.

Last edited by kernow; 2 Hours Ago at 19:00. Reason: Title was not clear enough

Source: http://www.thestudentroom.co.uk/showthread.php?t=2315128

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Tuesday, April 9, 2013

Windy spring storm sweeps through Calif., Arizona

LOS ANGELES (AP) ? Powerful winds raked much of California on Monday, toppling trees, spreading wildfires, causing scattered power outages, whipping up blinding dust storms, and sending waves crashing ashore as a vigorous spring weather system swept through the state on its way across the West.

Rising winds were reported in Arizona, where 34 miles of Interstate 40 near Winslow were closed to traffic.

In Phoenix, blowing dust obscured the mountains surrounding the city, and at least four people were injured in a pileup when two semi-trucks jackknifed in a dust storm on I-10 in southern Arizona. The injuries were not life-threatening.

New Mexico was expected to start feeling the impact late Monday, and in Colorado, the blustery system was expected to bring up to 2 feet of snow.

Northern California was first to feel the lashing blasts, which spread to the Sacramento and San Joaquin valleys.

At least a dozen trees came down in San Francisco, police officer John Tozzini told KGO-TV, which reported that more than 20,000 utility customers lost power in the region. A swath of electrical outages occurred across the Sacramento Municipal Utility District, the Sacramento Bee reported.

The wind sent a tree smashing into a Sacramento home where four friends were playing cards, but they didn't stop the game, according to KCRA-TV.

"It could've been worse," said Dodie Backus, who lives in the house.

"It's not going to stop our bridge game," said her game partner, Marilyn Baker.

The northwest-to-north winds were punctuated with gusts topping 80 mph at some Southern California points.

The blustery system was being fueled by a cold front.

"It's just a cold, really strong upper low," said Carol Smith, a meteorologist with the National Weather Service in Oxnard, Calif.

Whitecaps flecked the Pacific Ocean along the California coast, where gale warnings and small craft advisories were posted. Recreational boaters were warned to stay in port. Wind-driven swells slapped over the tops of breakwaters and turned waves into a churning froth under piers at points such as Redondo Beach and Manhattan Beach on the Los Angeles County coast.

The wind turned small wildfires into big problems in some areas, including a blaze in Fillmore about 50 miles northwest of Los Angeles that burned two homes and forced the evacuation of 84 homes.

Blowing dust forced the California Highway Patrol to close state Route 14 in the high desert Antelope Valley north of Los Angeles due to low visibility. Officer Michael Farrell said minor accidents occurred as motorists stopped and were hit from behind by other cars. No major injuries were reported.

The power went out for more than 14,000 customers in the Los Angeles area because of the winds.

Areas of the north San Fernando Valley experienced outages as tree branches tangled with power lines in at least two areas, said Michelle Vargas, spokeswoman for the Los Angeles Department of Water and Power.

Southern California Edison reported major weather-related outages throughout the San Gabriel Valley, with the lights out for thousands of customers in Rosemead, Monterey Park and Altadena.

In Ventura County, the power was out for more than 1,000 homes at the height of the winds, and nearly 300 homes in Orange County lost power.

About 2,700 homes were without power because of at least five downed utility poles in the remote desert area of Borrego Springs in San Diego County, according to Amber Albrecht, spokeswoman for San Diego Gas and Electric.

Air quality alerts were issued for northern Santa Barbara County and adjacent southern San Luis Obispo County because of blowing dust and sand.

The massive rush of air also had an upside. California's main power grid manager, the Independent System Operator, reported that turbines spinning within the ISO grid produced a record of 4,196 megawatts Sunday. The previous record was 3,944 megawatts on March 3. __

Associated Press writers Greg Risling and John Antczak in Los Angeles; Paul Davenport and Walter Berry in Phoenix; and Colleen Slevin in Denver contributed to this story.

Source: http://news.yahoo.com/windy-spring-storm-sweeps-calif-arizona-034919431.html

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Novel drug combination showed antitumor activity in patients with incurable BRCA-deficient cancers

Apr. 7, 2013 ? When given sequentially, two orally available experimental drugs -- sapacitabine and seliciclib -- worked together to elicit antitumor effects in patients with incurable BRCA-deficient cancers, according to phase I data presented at the AACR Annual Meeting 2013, held in Washington, D.C., April 6-10. There are no drugs yet approved specifically for this patient population.

"Since we began to enroll predominantly patients who carried a BRCA mutation in the study, we have seen several responses among those patients, as well as instances of prolonged stable disease lasting more than a year," said Geoffrey Shapiro, M.D., Ph.D., associate professor of medicine at Dana-Farber Cancer Institute and Harvard Medical School in Boston, Mass.

Shapiro and colleagues initially designed the phase I study to exploit preclinical results that suggested that sapacitabine and seliciclib worked together synergistically. Sapacitabine is an oral nucleoside analogue that induces single-strand damage to DNA. If the damaged DNA is not repaired, it ultimately results in cell death. Repair of sapacitabine-induced DNA damage requires BRCA proteins, suggesting that BRCA-deficient cancers may be particularly sensitive.

Seliciclib inhibits cyclin-dependent kinases (CDKs); CDK inhibition has been shown to augment cancer cell death induced by drugs like sapacitabine by multiple mechanisms, in part by suppressing DNA repair pathways.

Researchers enrolled 38 patients with incurable solid tumors and adequate organ function. They assigned patients to treatment with sapacitabine twice daily for seven days followed by seliciclib twice daily for three days.

Four patients with BRCA-deficient pancreatic, breast or ovarian cancers had confirmed ongoing partial responses to the drug combination. Three patients are experiencing partial responses, with the longest lasting more than 78 weeks.

Furthermore, researchers observed stable disease of 12 weeks or more in eight additional patients, including two patients with ovarian and breast cancers who carried the BRCA mutation and whose stable disease lasted 64 weeks and 21 weeks, respectively.

The maximum tolerated doses were 50 mg sapacitabine twice daily and 1,200 mg seliciclib twice daily. Dose-limiting toxicities included reversible transaminase elevations and neutropenia. Adverse events were mild to moderate in intensity.

Results of skin biopsies after treatment showed a 2.3-fold increase in DNA damage induced by sapacitabine, as measured by gamma-H2AX immunohistochemistry. Additional DNA damage occurred after treatment with seliciclib with a 0.58-fold further increase in gamma-H2AX staining.

"Initially in the dose-escalation phase of the trial, this combination produced stable disease of modest duration in some patients, which has been the experience with sapacitabine and CDK inhibitors in solid tumors," Shapiro said. "However, other published research during the course of the study indicated the role of the homologous recombination pathway, dependent on BRCA proteins, for repair of sapacitabine-induced DNA damage. Additionally, the CDK proteins were implicated in DNA repair pathways. These findings prompted us to enroll patients with advanced cancer who had the BRCA mutation and led to the first partial responses and instances of durable stable disease."

Based on these emerging results, Shapiro and colleagues continue to enroll appropriate patients in the trial, where the combination has been most efficacious. Additional schedules of the combination therapy are under evaluation. According to Shapiro, if further work continues to confirm BRCA mutation status as a potential biomarker for response, these drugs, both individually and in combination, should ultimately be evaluated in larger groups of patients who carry BRCA mutation. If successful, these drugs may provide an important treatment alternative for patients with BRCA-deficient cancers.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/E70r6AgCkpg/130407183555.htm

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Rapid climate change and the role of the Southern Ocean

Apr. 8, 2013 ? Scientists from Cardiff University and the University of Barcelona have discovered new clues about past rapid climate change.

The research, published this month in the journal Nature Geoscience, concludes that oceanographic reorganisations and biological processes are linked to the supply of airborne dust in the Southern Ocean and this connection played a key role in past rapid fluctuations of atmospheric carbon dioxide levels, an important component in the climate system.

The scientists studied a marine sediment core from the Southern Ocean and reconstructed chemical signatures at different water depths using stable isotope ratios in the shells of foraminifera, single-celled marine organisms. They found that the chemical difference between intermediate level and deep waters over the last 300,000 years closely resembled the changes in atmospheric carbon dioxide levels and the input of windblown dust.

Dr Martin Ziegler, School of Earth and Ocean Sciences, explained: "The deep ocean is by far the largest pool of available carbon on short timescales. In the Southern Ocean, water from the deep rises to the sea surface and comes in contact with the atmosphere. These waters will release their carbon to the atmosphere unless marine phytoplankton captures this carbon through photosynthesis and transports it back into the deep when it dies and sinks. The efficiency of this biological activity in the Southern Ocean is thought to depend on the input of nutrients, namely iron, contained in wind blown dust. It is also this efficiency that determines the strength of chemical stratification in the Southern Ocean."

Professor Ian Hall, School of Earth and Ocean Sciences, added: "Our study finds large changes in chemical stratification of the Southern Ocean not only across the shifts from ice ages to warm interglacial conditions, but also on more rapid, millennial timescales. However, changes in dust flux on these short timescales are much smaller. This could suggest that the biological response to a change in dust input is much more sensitive when the dust flux is relatively low such as it is today. This iron fertilization process might be therefore more important than previously thought."

These findings provide an important benchmark for climate modeling studies and more research will be needed to determine the significance and impact of future changes in dust input into the Southern Ocean.

The research was supported by the Natural Environment Research Council and is part of the international Gateways training network, funded by the 7th Framework Programme of the European Union.

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Journal Reference:

  1. Martin Ziegler, Paula Diz, Ian R. Hall, Rainer Zahn. Millennial-scale changes in atmospheric CO2 levels linked to the Southern Ocean carbon isotope gradient and dust flux. Nature Geoscience, 2013; DOI: 10.1038/ngeo1782

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/ce-5IZpPaJA/130408133752.htm

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Monday, April 1, 2013

Big depositors in Cyprus could lose up to 60 percent of savings

By Karolina Tagaris, Reuters

Major depositors in Cyprus's biggest bank will lose around 60 percent of savings over 100,000 euros, its central bank confirmed on Saturday, sharpening the terms of a bailout that has shaken European banks and saved the island from bankruptcy.

Initial signs that big depositors in Bank of Cyprus would take a hit of 30 to 40 percent - the first time the euro zone has made bank customers contribute to a bailout - had already unnerved investors in European lenders this week.

But the official decree published on Saturday confirmed a Reuters report a day earlier that the bank would give depositors shares worth just 37.5 percent of savings over 100,000 euros. The rest of such holdings might never be paid back.


The toughening of the terms will send a clear signal that the bailout means the end of Cyprus as a hub for offshore finance and could accelerate economic decline on the island and bring steeper job losses.

Banks reopened to relative calm on Thursday after an almost two-week shutdown and the imposition of capital controls. The streets of Nicosia were calm on Saturday, filled with crowds relaxing in its cafes and bars.

There is no sign for now that ordinary customers in other struggling euro zone countries like Greece, Italy or Spain are taking fright at the precedent set by the bailout.

"Cyprus is and will remain a special one-off case," German Finance Minister Wolfgang Schaeuble, one of the architects of the euro zone's response to a debt crisis now in its fourth year, told German mass-selling daily Bild.

"The savings accounts in Europe are safe."

European officials have worked hard this week to stress that the island's bailout was a unique case - after a suggestion by Eurogroup chairman Jeroen Dijsselbloem that the rescue would serve as a model for future crises rattled European financial markets.

"Together in the Eurogroup we decided to have the owners and creditors take part in the costs of the rescue - in other words those who helped cause the crisis," said Schaeuble.

"Cyprus's economy will now go through a long and painful period of adjustment. But then it will pay back the loan when it is on a solid economic foundation."

Cypriot President Nicos Anastasiades said on Friday that the 10-billion euro ($13 billion) bailout had contained the risk of national bankruptcy and would prevent it from leaving the euro.

Cypriots, however, are angry at the price attached to the rescue - the winding down of the island's second-largest bank, Cyprus Popular Bank, also known as Laiki, and an unprecedented raid on deposits over 100,000 euros.

Etyk, a bank worker's union, called a rally outside parliament for Thursday to protest against potential job cuts and a hit on their pension funds.

Copyright 2013 Thomson Reuters. Click for restrictions.

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AP: Gas trade group seeks fracking probe

ALBANY, N.Y. (AP) ? A formal complaint filed with New York's lobbying board asks it to investigate whether Artists Against Fracking, a group that includes Yoko Ono and other A-List celebrities, is violating the state's lobbying law, according to the document obtained by The Associated Press.

The Independent Oil & Gas Association, an industry group that supports gas drilling, filed the complaint Tuesday with the state's Joint Commission on Public Ethics.

The complaint is based on an AP story that found that Artists Against Fracking and its members, including Ono, her son Sean Lennon, actors Mark Ruffalo and Robert De Niro and others, aren't registered as lobbyists and therefore didn't disclose their spending in opposition to hydraulic fracturing, or fracking, to remove gas from underground deposits.

"The public has been unable to learn how much money is being spent on this effort, what it is being spent on, and who is funding the effort," said Brad Gill, executive director of the Independent Oil & Gas Association of New York. "I understand the power of celebrity that this organization has brought to the public discussion over natural gas development, but I do not understand why this organization is not being required to follow the state's lobbying law."

The group confirmed it filed the complaint but didn't comment further.

Artists Against Fracking, formed by Ono and Lennon, says its activities are protected as free speech. The group was created last year amid the Cuomo administration's review to determine whether to allow hydraulic fracturing to remove gas from vast underground shale formations in southern and central New York.

Gov. Andrew Cuomo continues his review as public opinion has shifted from initial support based on the promise of jobs and tax revenue from drilling in economically depressed upstate New York to mixed feelings because of concerns over potential environmental and health effects.

Seven months after Artists Against Fracking was formed, the Quinnipiac University Polling Institute on March 20 found that New York voters were for the first time opposed to fracking, 46 percent to 39 percent.

"There's no doubt the celebrities had an effect," Quinnipiac pollster Maurice Carroll said. "As far as I can tell, they made all the difference."

A spokesman for Artists Against Fracking said the group and its individual members don't have to register as lobbyists.

"As private citizens, Yoko and Sean are not required to register as lobbyists when they use their own money to express an opinion and there's also no lobbying requirement when you are engaged in a public comment period by a state agency," spokesman David Fenton said.

"If the situation changes then, of course, Artists Against Fracking will consider registering," Fenton said. "Up to now, there has been no violation because they are entitled to do this as private citizens with their own money."

On its website, the group implores readers: "Tell Governor Cuomo: Don't Frack New York." Celebrities supporting the group have led rallies and performed in the song "Don't Frack My Mother," also carried on the Internet.

Ethics commission spokesman John Milgrim didn't immediately respond to a request for comment on Friday. By law, the commission doesn't confirm or deny pending investigations.

New York's former lobbying regulator, attorney David Grandeau, said he believed the group and the supporting artists, including musicians Paul McCartney and Lady Gaga and actress Anne Hathaway, should be registered and required to disclose details on their efforts to spur public opposition to gas drilling.

"When you are advocating for the passage or defeat of legislation or proposed legislation and spend more than $5,000, you are required to register," Grandeau said Friday. "Just because you are a celebrity doesn't mean that lobbing laws don't apply to you. Your celebrity status does not protect you in Albany."

Hip-hop mogul Russell Simmons and developer Donald Trump are among the high-profile figures who clashed with the commission when Grandeau was regulator. The biggest penalty for failure to follow the lobbying law resulted in a $250,000 fine against Trump and others over casinos in 2000.

Source: http://news.yahoo.com/apnewsbreak-gas-trade-group-seeks-fracking-probe-172054771.html

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